Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays

2026/01/13 by Ishminder Kaur, Bennett Shaw, Ashrit Multani +11 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Acute Myeloid Leukemia Research #Cancer Genomics and Diagnostics #Genomics and Rare Diseases

paper · pdf · doi:10.1017/ice.2025.10390

openalex publication_date 2026/01/13 · openalex created_date 2026/01/14 · openalex updated_date 2026/07/30

Abstract

This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.

Citations

• Quantitative Microbial Cell-Free DNA Sequencing From Plasma: A Potential Biomarker for the Diagnosis of Staphylococcal Infection of Cardiac Implantable Electronic Devices

Discussions

• New in ICHE: Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays ▶️ Authors find that only 5/173 cases of serial plasma metagenomic next-generation sequencin [bsky, 6 points, 0 comments]

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