Increasing plasma sodium with Tolvaptan under regulated water intake: comparison with hypertonic saline

2026/03/26 by Nabil William Sweis, Jennifer Tuazon, Yusra Cheema +3 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · Psychology · #Electrolyte and hormonal disorders #Ion Transport and Channel Regulation #Neuroendocrine regulation and behavior

paper · doi:10.1152/ajprenal.00049.2026

Abstract

This study shows that the rise in plasma sodium induced by the vasopressin V2-receptor antagonist Tolvaptan can be controlled by regulating water intake to under-replace urine output by a fixed amount per kilogram body weight in healthy subjects. This approach produced increases in plasma sodium that were comparable to hypertonic saline and provides a means to prevent rapid rises in plasma sodium beyond the target rate.

Discussions

• Pleased to share this study by Nabil Sweis et al. in AJP-Renal where we report for the first time a comparison of Tolvaptan vs hypertonic saline to increase plasma sodium in normal volunteers doi.org [bsky, 6 points, 0 comments]

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