2024/08/06 by Jincan Chen, Héctor Sánchez-Iranzo, Nicolas Diotel +1 · 1 voice · 4 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Neurogenesis and neuroplasticity mechanisms #Neuroinflammation and Neurodegeneration Mechanisms #Zebrafish Biomedical Research Applications
paper · pdf · doi:10.1111/febs.17231
openalex publication_date 2024/08/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Regeneration, the complex process of restoring damaged or absent cells, tissues, and organs, varies considerably between species. The zebrafish is a remarkable model organism for its impressive regenerative abilities, particularly in organs such as the heart, fin, retina, spinal cord, and brain. Unlike mammals, zebrafish can regenerate with limited or absent scarring, a phenomenon closely linked to the activation of stem cells and immune cells. This review examines the unique roles played by the immune response and inflammation in zebrafish and mouse during regeneration, highlighting the cellular and molecular mechanisms behind their divergent regenerative capacities. By focusing on zebrafish telencephalic regeneration and comparing it to that of the rodents, this review highlights the importance of a well-controlled, acute, and non-persistent immune response in zebrafish, which promotes an environment conducive to regeneration. The knowledge gained from understanding the mechanisms of zebrafish regeneration holds great promises for the treatment of human neurodegenerative diseases and brain damage (stroke and traumatic brain injuries), as well as for the advancement of regenerative medicine approaches.