Mindful diagnostics: a central nervous system infection case study

2026/01/01 by Jonathan H. Ryder, Sarah E. Turbett · 1 voice
Immunology and Microbiology · Medicine · #Bacterial Infections and Vaccines #Infectious Encephalopathies and Encephalitis #Whipple's Disease and Interleukins

paper · pdf · doi:10.1017/ash.2026.10357

openalex publication_date 2026/01/01 · openalex created_date 2026/04/11 · openalex updated_date 2026/05/21

Abstract

A clinical case is presented to discuss a framework for use of advanced diagnostics for central nervous system infections. Advantages, limitations, and diagnostic stewardship strategies are discussed for each modality: multiplex molecular meningitis/encephalitis panel, plasma microbial cell-free DNA sequencing, and cerebrospinal fluid metagenomic next generation sequencing.

Citations

• Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections
• Metagenomic Next-generation Sequencing in Patients With Infectious Meningoencephalitis: A Comprehensive Systematic Literature Review and Meta-analysis

Discussions

• @jonathanrydermd.bsky.social: A CNS infection case is used as a framework for discussion of advanced CNS diagnostics, including diagnostic stewardship of multiplex PCR meningitis panels, plasma mcfDNA [bsky, 6 points, 0 comments]

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