A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics

2026/06/24 by Rodion Gordzevich, R. Gordzevich, M. Xu +20 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biotin and Related Studies #Cyclopropane Reaction Mechanisms #Microbial Natural Products and Biosynthesis

paper · doi:10.1038/s41586-026-10647-9

openalex publication_date 2026/06/24 · openalex created_date 2026/06/25 · openalex updated_date 2026/07/23

Citations

• IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era
• Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
• Natural products in drug discovery: advances and opportunities
• antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation
• phytools 2.0: an updated R ecosystem for phylogenetic comparative methods (and other things)

Discussions

• While some might argue that the golden age of Streptomyces in antibiotic discovery has passed, these organisms can still surprise us 🦠🧫🔬🤓 #microbiology #antibiotics #NaturalProducts #MicroSky @nat [bsky, 6 points, 0 comments]