Side-by-side regions in dorsolateral prefrontal cortex estimated within the individual respond differentially to domain-specific and domain-flexible processes

2023/11/08 by Lauren M. DiNicola, Wendy Sun, Randy L. Buckner · 1 voice
Medicine · Neuroscience · #Advanced Neuroimaging Techniques and Applications #Functional Brain Connectivity Studies #Neurobiology of Language and Bilingualism

paper · doi:10.1152/jn.00277.2023

openalex publication_date 2023/11/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

Competing hypotheses link regions of prefrontal cortex (PFC) to domain-flexible or domain-specific processes. Here, using a precision neuroimaging approach, we identify a domain-specialized region in dorsolateral PFC, coupled to the medial temporal lobe and recruited for scene construction. This region is juxtaposed to, but distinct from, broader PFC regions recruited flexibly for cognitive control. Region distinctions align with broader network differences, suggesting that PFC regions gain dissociable processing properties via segregated anatomical projections.

Citations

• The organization of the human cerebral cortex estimated by intrinsic functional connectivity
• Function in the human connectome: Task-fMRI and individual differences in behavior
• Spatial Topography of Individual-Specific Cortical Networks Predicts Human Cognition, Personality, and Emotion
• The role of PFC networks in cognitive control and executive function
• The role of prefrontal cortex in cognitive control and executive function

Discussions

• Side-by-side regions in dorsolateral prefrontal cortex estimated within the individual respond differentially to domain-specific and domain-flexible processes doi.org/10.1152/jn.0... #neuroscience [bsky, 7 points, 0 comments]

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