2024/05/24 by Maxwell G. Heiman, Hannes E. Bülow · 1 voice
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Circadian rhythm and melatonin #Genetics, Aging, and Longevity in Model Organisms #Photoreceptor and optogenetics research
paper · pdf · doi:10.1093/genetics/iyae056
openalex publication_date 2024/05/24 · openalex created_date 2024/05/25 · openalex updated_date 2026/07/28
Since the days of Ramón y Cajal, the vast diversity of neuronal and particularly dendrite morphology has been used to catalog neurons into different classes. Dendrite morphology varies greatly and reflects the different functions performed by different types of neurons. Significant progress has been made in our understanding of how dendrites form and the molecular factors and forces that shape these often elaborately sculpted structures. Here, we review work in the nematode Caenorhabditis elegans that has shed light on the developmental mechanisms that mediate dendrite morphogenesis with a focus on studies investigating ciliated sensory neurons and the highly elaborated dendritic trees of somatosensory neurons. These studies, which combine time-lapse imaging, genetics, and biochemistry, reveal an intricate network of factors that function both intrinsically in dendrites and extrinsically from surrounding tissues. Therefore, dendrite morphogenesis is the result of multiple tissue interactions, which ultimately determine the shape of dendritic arbors.