2025/01/09 by Yaojie Kong, Jingyao Li, Xueyao Zhao +2 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #CAR-T cell therapy research #Nanowire Synthesis and Applications #Virus-based gene therapy research
paper · pdf · doi:10.3389/fimmu.2024.1519671
openalex publication_date 2025/01/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging. This review summarized the development of CAR-T technologies, emphasized the challenges and solutions in CAR-T cell therapy for solid tumors. Also, key innovations were discussed including specialized CAR-T, combination therapies and the novel use of CAR-Treg, CAR-NK and CAR-M cells. Besides, CAR-based cell therapy have extended its reach beyond oncology to autoimmune disorders. We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. By highlighting these cutting-edge developments, this review underscores the transformative potential of CAR technologies in clinical practice.