2025/03/21 by Fangyuan Chen, Hanfang Zhang, Kang Cai +1 · 1 voice
Chemistry · #Mass Spectrometry Techniques and Applications #Molecular Sensors and Ion Detection #Supramolecular Chemistry and Complexes
paper · doi:10.1016/j.supmat.2025.100101
openalex publication_date 2025/03/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
High-affinity molecular recognition plays a crucial role in both biological and artificial host-guest systems, ensuring robustness in complex environments or at extremely low concentrations. Achieving exceptionally high binding affinity in artificial receptors remains a fundamental challenge for supramolecular chemistry. However, while ultrahigh binding affinity is desirable for stability, it may limit the dynamic behavior of host-guest systems, thereby restricting potential applications. Hence, controllable ultrahigh-affinity molecular recognition ( CUAMR ) systems allow guest release in response to precise stimuli (such as photo, pH and redox), which hold significant promise across diverse fields. This paper focuses on the introduction of CUAMR and functional applications of such controllable systems, highlighting current challenges and future prospects.