Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
2025/04/10 by Kil Sun Lee, Xiaoyang Su, Tao Huan · 3 voices
Biochemistry, Genetics and Molecular Biology · #Metabolomics and Mass Spectrometry Studies #Nutrition, Genetics, and Disease #Bioinformatics and Genomic Networks
paper · doi:10.1038/s42255-025-01283-0
Discussions
- Interesting critique in Nature Metabolism on misusing gene-centric tools for #metabolomics data 🧪.
Turns out metabolites ≠ genes🧬—and forcing them into gene-style pathway analysis can really skew r [bsky, 7 points, 0 comments]
- Pathway analysis isn’t one-size-fits-all: what works for gene expression can mislead in metabolomics. This sharp piece explains why metabolite data require biological context, careful annotation, and [bsky, 5 points, 0 comments]
- Some really nice points outlining the misuse of metabolomics in pathway analysis.
To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite [bsky, 4 points, 0 comments]