Immune Mechanisms in Pulmonary Fibrosis

2016/05/05 by Saeed Kolahian, Isis E. Fernandez, Oliver Eickelberg +1
Medicine · #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis #Neonatal Respiratory Health Research #Pleural and Pulmonary Diseases

paper · doi:10.1165/rcmb.2016-0121tr

openalex publication_date 2016/05/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and progressive disease with high mortality and limited therapeutic options. Excessive deposition of extracellular matrix proteins results in fibrotic remodeling, alveolar destruction, and irreversible loss of lung function. Both innate and adaptive immune mechanisms contribute to fibrogenesis at several cellular and noncellular levels. Here, we summarize and discuss the role of immune cells (T cells, neutrophils, macrophages, and fibrocytes) and soluble mediators (cytokines and chemokines) involved in pulmonary fibrosis, pointing toward novel immune-based therapeutic strategies in the field.

Citations

• Role of Sonic Hedgehog in idiopathic pulmonary fibrosis
• Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell

Related

• Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in pulmonary fibrosis
• The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis
• Mechanisms of Pulmonary Fibrosis
• Pulmonary fibrosis: patterns and perpetrators
• Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis