Impact of Charge Reduction on Sequence Coverage of Proteins by 193 nm Ultraviolet Photodissociation

2025/09/09 by Sean D. Dunham, Mohamed I. Gadallah, Jennifer S. Brodbelt

paper · doi:10.1021/jasms.5c00230

Citations

• Leveraging Ion–Ion and Ion–Photon Activation to Improve the Sequencing of Proteins Carrying Multiple Disulfide Bonds: The Human Serum Albumin Case Study
• Enhancing Top-Down Analysis of Proteins by Combining Ultraviolet Photodissociation (UVPD), Proton-Transfer Charge Reduction (PTCR), and Gas-Phase Fractionation to Alleviate the Impact of Nondissociated Precursor Ions
• Top-Down Analysis of Supercharged Proteins Using Collision-, Electron-, and Photon-Based Activation Methods
• Sequential Ion–Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer
• Ion-Ion Proton Transfer and Parallel Ion Parking for the Analysis of Mixtures of Intact Proteins on a Modified Orbitrap Mass Analyzer
• Generation of Charge-Reduced Ions of Membrane Protein Complexes for Native Ion Mobility Mass Spectrometry Studies
• Analysis of Native-Like Proteins and Protein Complexes Using Cation to Anion Proton Transfer Reactions (CAPTR)
• Mutual storage mode ion/ion reactions in a hybrid linear ion trap