1992/01/01 by Matthew L. Johnson, Matthew M. Robinson, K. Sreekumaran Nair +2
Biochemistry, Genetics and Molecular Biology · Health Professions · Medicine · #Adipose Tissue and Metabolism #Mitochondrial Function and Pathology #Muscle Physiology and Disorders #Radiation Dose and Imaging #Radioactivity and Radon Measurements
paper · doi:10.1016/j.tem.2012.12.003
openalex publication_date 1992/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.