The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice

2024/10/29 by John McGovern, Carrighan Perry, Alexander Ghincea +3
Medicine · #Asthma and respiratory diseases #Inhalation and Respiratory Drug Delivery #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

paper · doi:10.1152/ajplung.00062.2024

openalex publication_date 2024/10/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/24

Abstract

The lung-adrenal axis plays a significant role in pulmonary fibrosis. Adrenalectomy provides protection against lung fibrotic ECM remodeling and lung inflammation by reducing the levels of lymphocytes in BAL and macrophages in lung of bleomycin-treated mice. Although compared with sham surgery, adrenalectomy raised collagen concentration in uninjured mice, there was no discernible difference in bleomycin-induced collagen accumulation. However, adrenalectomy significantly reversed the enhanced expression and colocalization of αSMA and fibronectin induced by bleomycin.

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