2024/11/19 by Lydia Finney, Lydia J. Finney, Peter Fenwick +13
Health Professions · Medicine · #Chronic Obstructive Pulmonary Disease (COPD) Research #Pediatric health and respiratory diseases #Respiratory viral infections research
paper · doi:10.1152/ajplung.00118.2024
openalex publication_date 2024/11/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/24
COPD exacerbations are commonly triggered by viral infections. Some patients with COPD have frequent exacerbations leading to rapid lung function decline and increased mortality. In this study, antiviral responses (interferons) from bronchial epithelial cells and alveolar macrophages were reduced in patients with COPD compared with healthy participants and further reduced in patients with COPD with frequent exacerbations. Impaired antiviral immunity may lead to frequent COPD exacerbations. Targeted vaccinations and antiviral therapy may reduce exacerbations in COPD.