Low tidal volume ventilation facilitates spontaneous increase in bronchoconstriction and air trapping that can be resolved by deep inspiration and bronchodilator

2025/07/01 by Yuto Yasuda, Geoffrey N. Maksym, Lu Wang +2
Medicine · Neuroscience · #Neonatal Respiratory Health Research #Neuroscience of respiration and sleep #Respiratory Support and Mechanisms

paper · doi:10.1152/ajplung.00085.2025

openalex publication_date 2025/07/01 · openalex created_date 2025/07/02 · openalex updated_date 2026/05/23

Abstract

We showed that air trapping is a consistent feature in ex vivo sheep lungs possessing spontaneous bronchoconstriction, when the lungs are ventilated with small tidal volume without intermittent deep inspirations. We further demonstrated that in the presence of salbutamol, air trapping does not occur. This explains the importance of deep inspirations in normal breathing and indicates that airway smooth muscle tone could result in air trapping in the absence of deep inspiration.

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