Mice with lymphatic dysfunction develop pathogenic lung tertiary lymphoid organs that model an autoimmune emphysema phenotype of COPD

2024/10/22 by Barbara Summers, Barbara D. Summers, Kihwan Kim +12
Medicine · #Cystic Fibrosis Research Advances #Lymphatic Disorders and Treatments #Lymphatic System and Diseases

paper · doi:10.1152/ajplung.00209.2024

openalex publication_date 2024/10/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The lymphatic vasculature has been implicated in the pathogenesis of lung disease but remains understudied. Here, the authors use a mouse model to show that lymphatic dysfunction leads to a phenotype of emphysema that is characterized by lung tertiary lymphoid organs that are autoreactive and pathogenic. Analysis of human tissue showed increased lymphatic markers in autoimmune emphysema with prominent TLOs, compared with other COPD phenotypes.

Citations

• Lymph flow regulates collecting lymphatic vessel maturation in vivo
• Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life
• Integrated analysis of multimodal single-cell data
• Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

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