Effects of maternal edible THC consumption on offspring lung growth and function in a rhesus macaque model

2025/02/04 by Lyndsey E. Shorey‐Kendrick, Lyndsey E. Shorey-Kendrick, Adam Crosland +15
Biochemistry, Genetics and Molecular Biology · Medicine · Nursing · #Adipose Tissue and Metabolism #Epigenetics and DNA Methylation #Fatty Acid Research and Health

paper · doi:10.1152/ajplung.00360.2024

openalex publication_date 2025/02/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

In a translational rhesus macaque model, chronic prenatal delta-9-tetrahydrocannabinol exposure resulted in decreased lung volumes in offspring measured at 6 mo of age. These decreases correlated with altered DNA methylation in the lung, including at genes involved in extracellular matrix organization, lung development, and activation of immune signaling, and changes in lung cell composition as measured by spatial transcriptomics. These findings add to the growing evidence that prenatal cannabis exposure may adversely affect offspring development.

Citations

• Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

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