Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks

2025/02/19 by Daniel Kurbanov, Daniel B. Kurbanov, Farida Ahangari +13 · 2 citations
Medicine · #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

paper · doi:10.1152/ajplung.00171.2024

openalex publication_date 2025/02/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Using epigenetic clocks, we found a notable acceleration of biological aging in IPF tissues, particularly in DunedinPACE, suggesting that the biological aging process in IPF is accelerated and closely related to the severity of the disease. The study also underscores DNA methylation's potential as a biomarker for IPF, as well as the dynamics of epigenetic aging and the need to consider biological age in medical research and healthcare.

Cited by

• The crucial role of normative ageing in respiratory pathogenesis
• Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis

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