Enhanced lung endothelial glycolysis is implicated in the development of severe pulmonary hypertension in type 2 diabetes

2024/10/22 by Qiuyu Zheng, Jody Tori O. Cabrera, Atsumi Tsuji-Hosokawa +7
Biochemistry, Genetics and Molecular Biology · Medicine · #Cardiovascular Function and Risk Factors #MicroRNA in disease regulation #Pulmonary Hypertension Research and Treatments

paper · doi:10.1152/ajplung.00305.2023

openalex publication_date 2024/10/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Increasing evidence shows that diabetes exacerbates the progression of pulmonary hypertension; however, its molecular mechanisms are understudied. In this study, we revealed that augmented glycolysis in diabetic pulmonary endothelial cells is involved in the development of severe PH in diabetes. Inhibition of glycolysis could be a therapeutic strategy for treating pulmonary hypertension in patients with diabetes.

Citations

• Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
• Metabolism in Pulmonary Hypertension

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