The extracellular matrix protein periostin is required for wound repair in primary human airway epithelia

2025/04/21 by Lorena A. Tran, Lorena Tran, Michael Catlin +10
Medicine · #Cardiac Fibrosis and Remodeling #Occupational exposure and asthma

paper · doi:10.1152/ajplung.00039.2025

Abstract

This article highlights the critical role of periostin (POSTN) in airway epithelial and fibroblast-mediated wound repair. Moreover, the study reveals a paracrine signaling loop between airway epithelial basal cells and lung fibroblasts, emphasizing periostin's therapeutic potential for diseases like asthma and idiopathic pulmonary fibrosis.

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