Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma

2025/01/27 by Vickram Tejwani, Rulin Wang, A.F. Villabona-Rueda +11
Immunology and Microbiology · Medicine · #Asthma and respiratory diseases #IL-33, ST2, and ILC Pathways

paper · doi:10.1152/ajplung.00270.2024

openalex publication_date 2025/01/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

This study identified unique contributors to asthma in children with obesity and found novel pathways. Increased expression of IL-7R, IL-32, PARP-1, FKBP5 gene, IL-6, and Rho transcriptional signaling were observed in obese individuals with asthma.

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