Mild and Efficient Synthesis of Sulfonyl Fluorides from Sulfonamides Enabled by Diethylaminosulfur Trifluoride

2025/06/27 by Friedrich Jurk, Manuel van Gemmeren · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Sulfur-Based Synthesis Techniques #Chemical Synthesis and Reactions #Fluorine in Organic Chemistry

paper · doi:10.1055/a-2645-0537

Abstract

Abstract A simple method for the synthesis of sulfonyl fluorides from secondary sulfonamides is described. The commercially available fluorinating agent diethylaminosulfur trifluoride (DAST) is used to efficiently transform structurally diverse secondary sulfonamides in high yields. We further demonstrate the utility of this method for the generation of sulfonamide compound libraries from a given sulfonamide starting material as well as the scalability of our method to gram scale reactions.

Discussions

• Congratulations to Friedrich Jurk, whose manuscript "Mild and Efficient Synthesis of Sulfonyl Fluorides from Sulfonamides Enabled by Diethylaminosulfur Trifluoride" has been accepted for publication i [bsky, 7 points, 1 comments]

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