Scope and Mechanism on Iridium‐f‐Amphamide Catalyzed Asymmetric Hydrogenation of Ketones

2018/06/20 by Zhiqin Liang, Tilong Yang, Guoxian Gu +3
Chemistry · Engineering · Pharmacology, Toxicology and Pharmaceutics · #Asymmetric Hydrogenation and Catalysis #Chemical Reactions and Isotopes #Surface Chemistry and Catalysis

paper · doi:10.1002/cjoc.201800129

openalex publication_date 2018/06/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Abstract A series of novel and easily accessed ferrocene‐based amino‐phosphine‐sulfonamide (f‐Amphamide) ligands have been developed and applied in Ir‐catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results (up to >99% conversion, >99% ee and TON up to 200 000). DFT calculations suggest an activating model involving an alkali cation Li + .

Citations

• Asymmetric Transfer Hydrogenation Catalyzed by Chiral Ruthenium Complexes

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