Photoredox Synthesis of Thio‐Functionalized Cyclic Ethers Using N ‐Sulfenyl Phthalimides as a Thiyl‐Radical Precursor

2023/04/25 by Maojian Lu, Rong‐Bin Liang, Can‐Ming Zhu +2

paper · doi:10.1002/cjoc.202300118

Abstract

Comprehensive Summary A visible‐light mediated exclusively regioselective synthesis of 2,2‐disubstituted thio‐functionalized tetrahydrofurans, tetrahydro‐ pyrans and oxepanes has been described through an operationally simple and mild photoredox protocol. Thiyl radical generated from N ‐phenylsulfenyl phthalimide by photoredox catalysis was proven to be the key reactive intermediate in this reaction.

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