Divergent Mono‐ and Di‐trifluoromethylthiolation of Bicyclo[1.1.0]butane and Bicyclo[2.1.0]pentane†

2025/07/25 by Pengfei Yang, Sihan Chen, Yu‐Xin Luan +1
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Fluorine in Organic Chemistry #Inorganic Fluorides and Related Compounds #Radical Photochemical Reactions

paper · doi:10.1002/cjoc.70194

openalex publication_date 2025/07/25 · openalex created_date 2025/08/04 · openalex updated_date 2026/07/30

Abstract

Comprehensive Summary Strain‐release ring‐opening trifluoromethylthiolation to construct SCF 3 ‐substituted cyclic motifs was under‐explored, and di‐trifluoromethylthiolation is unachieved. Herein, we present the first trifluoromethylthiolation of bicyclo[1.1.0]butane (BCB) and bicyclo[2.1.0]pentane. By employing different activators, both mono‐ and di‐trifluoromethylthio substituted cyclobutane and cyclopentane derivatives were successfully obtained.

Citations

• A survey of Hammett substituent constants and resonance and field parameters

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