Structure-Based Characterization of Multiprotein Complexes

2014/06/19 by Markus Wiederstein, Markus Gruber, Karl Frank +4
Biochemistry, Genetics and Molecular Biology · Materials Science · #Enzyme Structure and Function #Microbial Metabolic Engineering and Bioproduction #Protein Structure and Dynamics

paper · pdf · doi:10.1016/j.str.2014.05.005

openalex publication_date 2014/06/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies.

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