2024/01/01 by Wisarut Kiratitanaporn, Jiaao Guan, Min Tang +6 · 1 voice · 1 citation
Engineering · #3D Printing in Biomedical Research #Additive Manufacturing and 3D Printing Technologies #Bone Tissue Engineering Materials
paper · pdf · doi:10.1039/d4bm00892h
openalex publication_date 2024/01/01 · openalex created_date 2024/10/16 · openalex updated_date 2026/07/22
model, three 3D-printed PGSA-based scaffold conditions were investigated: (1) a scaffold with muscle-informed mechanical properties in its entirety without zonal stiffness regions, (2) a scaffold with one end possessing native muscle stiffness and the other end possessing native tendon stiffness, and (3) a scaffold with three distinct regions whose stiffness values correspond to those of muscle on one end of the scaffold, MTJ in the middle junction of the scaffold, and tendon on the other end of the scaffold. The scaffold containing regional mechanical heterogeneity most similar to the native MTJ (condition 3) was found to enhance the expression of MTJ-related markers compared to those without the presence of zonal stiffness regions. Overall, the DLP-based 3D printing platform and biomaterial system developed in this study could serve as a useful tool for mimicking the complexity of the native MTJ, which possesses inherent geometric and mechanical heterogeneity.