Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

2020/05/30 by James M. Wood, Nishikant S. Satam, Nishikant Satam +13 · 27 citations
Chemistry · Medicine · #Annulation #Antiparasitic #Benznidazole #Bicyclic molecule #Biochemistry #Catalysis #Chagas disease #Chemical synthesis #Chemistry #Combinatorial chemistry #Enantioselective synthesis #In vitro #Nitroalkene #Organic chemistry #Parasite hosting #Phthalide #Quinone #Stereochemistry #Synthesis and Biological Evaluation #Synthesis and Catalytic Reactions #Trypanosoma cruzi #Trypanosoma species research and implications #Virology

paper · pdf · doi:10.1016/j.bmc.2020.115565

published in Bioorganic & Medicinal Chemistry 28(15), 115565 (Elsevier BV)

openalex publication_date 2020/05/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• ORTEP-3 for Windows - a version ofORTEP-III with a Graphical User Interface (GUI)
• WinGXsuite for small-molecule single-crystal crystallography
• Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries
• Congenital Chagas disease: current diagnostics, limitations and future perspectives
• Chagas disease
• Chagas’ Disease