Structure-alignment-driven cross-graph modeling for functional RNA design

2026/07/30

paper · doi:10.1038/s43588-026-01029-2

Abstract

Nature Computational Science, Published online: 30 July 2026; doi:10.1038/s43588-026-01029-2 This study presents AlignIF, which uses multiple structure alignments to capture evolutionary rules and conservation patterns across RNA families, enabling diverse, structure-guided designs of functional aptamers and ribozymes.

Related

• Structural alignments to design functional RNAs
• RiboFlow: Conditional De Novo RNA Co-Design via Synergistic Flow Matching
• Bridging Sequence-Structure Alignment in RNA Foundation Models
• Computational approaches for RNA structure prediction and design
• RNAmountAlign: efficient software for local, global, semiglobal pairwise and multiple RNA sequence/structure alignment