2023/11/10 by Erik S. Knudsen, Agnieszka K. Witkiewicz, Seth M. Rubin · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Breast Cancer Therapies #Cancer-related Molecular Pathways #Microtubule and mitosis dynamics
paper · doi:10.1016/j.tcb.2023.10.007
openalex publication_date 2023/11/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
In the commonly accepted paradigm for control of the mammalian cell cycle, sequential cyclin-dependent kinase (CDK) and cyclin activities drive the orderly transition from G1 to S phase. However, recent studies using different technological approaches and examining a broad range of cancer cell types are challenging this established paradigm. An alternative model is evolving in which cell cycles utilize different drivers and take different trajectories through the G1/S transition. We are discovering that cancer cells in particular can adapt their drivers and trajectories, which has important implications for antiproliferative therapies. These studies have helped to refine an understanding of how CDK inhibition impinges on proliferation and have significance for understanding fundamental features of cell biology and cancer.