Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

2016/06/12 by Thanh N. Nguyen, Thanh Ngoc Nguyen, Benjamin S. Padman +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Parkinson's Disease Mechanisms and Treatments #Ubiquitin and proteasome pathways

paper · doi:10.1016/j.tcb.2016.05.008

openalex publication_date 2016/06/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Citations

• Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy
• The Ubiquitin Code
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
• PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

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• Mitochondrial pyruvate dehydrogenase kinase 1 drives bevacizumab resistance and malignant phenotype of TNBC by enhancing mitophagy