2025/03/28 by Hanna Salmonowicz, Karolina Szczepanowska
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Metabolism and Genetic Disorders #Mitochondrial Function and Pathology
paper · doi:10.1016/j.tcb.2025.02.008
openalex publication_date 2025/03/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
While mitochondrial dysfunction is one of the canonical hallmarks of aging, it remains only vaguely defined. Its core feature embraces defects in energy-producing molecular machinery, the mitochondrial respiratory complexes (MRCs). The causes and consequences of these defects hold research attention. In this review, we assess the lifecycle of respiratory complexes, from biogenesis to degradation, and look closely at the mechanisms that could underpin their dysfunction in aged cells. We discuss how these processes could be altered by aging and expand on the fate of MRCs in age-associated pathologies. Given the complexity behind MRC maintenance and functionality, several traits could contribute to the phenomenon known as age-associated mitochondrial dysfunction. New advances will help us better understand the fate of this machinery in aging and age-related diseases.