Roles for primary cilia in synapses and neurological disorders

2024/11/25 by Polina Volos, Kenshiro Fujise, Nisha Mohd Rafiq · 1 voice
Biochemistry, Genetics and Molecular Biology · #Amino Acid Enzymes and Metabolism #Genetic and Kidney Cyst Diseases #Mitochondrial Function and Pathology

paper · doi:10.1016/j.tcb.2024.10.014

openalex publication_date 2024/11/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

The role of primary cilia has recently garnered significant attention in the field of neurodegeneration. This review explores the diversity of primary cilia in the mature brain and their interrelationships with a multitude of cellular structures, including axons and synapses. Importantly, an overview of the growing prominence of ciliary-related dysfunctions in neurodegenerative diseases is summarized, with a special emphasis on Parkinson's disease (PD) and neuropsychiatric disorders.

Discussions

• This is a strange and surprising finding. Need to study the electron micrographs in the suppl material carefully (without the colourful shading) to learn more. Note that neurons can have cilia, I wond [bsky, 2 points, 0 comments]

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