2010/01/01 by Michael A. Bruckman, J. Liu, Jie Liu +6
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Engineering · #Advanced biosensing and bioanalysis techniques #Biosensors and Analytical Detection #Plant Virus Research Studies
paper · doi:10.1039/c0jm00634c
openalex publication_date 2010/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
A thin film sensor for the detection of volatile organic compounds (VOC) was fabricated by deposition of oligo-aniline grafted tobacco mosaic virus (TMV) onto a glass substrate. The oligo-aniline motifs were conjugated onto the TMV surface by a traditional diazonium coupling reaction to tyrosine residues followed by Cu(I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The modified TMV was easily fabricated into a thin film by directly drop coating onto a glass substrate. Upon integration of the glass substrate into a prototypical device, the virus-based thin film exhibited good sensitivity and selectivity toward ethanol and methanol vapour.