2005/03/10 by Ravichandran Ramasamy, Susan J. Vannucci, Shirley Shi Du Yan +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Advanced Glycation End Products research #Natural Antidiabetic Agents Studies #Neuroinflammation and Neurodegeneration Mechanisms
paper · pdf · doi:10.1093/glycob/cwi053
openalex publication_date 2005/03/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced glycation end products (AGEs), accumulate in a wide variety of environments. AGEs may be generated rapidly or over long times stimulated by a range of distinct triggering mechanisms, thereby accounting for their roles in multiple settings and disease states. A critical property of AGEs is their ability to activate receptor for advanced glycation end products (RAGE), a signal transduction receptor of the immunoglobulin superfamily. It is our hypothesis that due to such interaction, AGEs impart a potent impact in tissues, stimulating processes linked to inflammation and its consequences. We hypothesize that AGEs cause perturbation in a diverse group of diseases, such as diabetes, inflammation, neurodegeneration, and aging. Thus, we propose that targeting this pathway may represent a logical step in the prevention/treatment of the sequelae of these disorders.