Inter-residue, inter-protein and inter-family coevolution: bridging the scales

2017/11/05 by Hendrik Szurmant, Martin Weigt · 4 citations
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Bioinformatics and Genomic Networks #Endoplasmic Reticulum Stress and Disease #Protein Structure and Dynamics #physics.bio-ph #q-bio.BM #q-bio.MN #q-bio.QM

paper · pdf · doi:10.1016/j.sbi.2017.10.014

published as Current Opinion in Structural Biology 50 (2018): 26-32 · 12 pages, review paper

openalex publication_date 2017/11/05 · arxiv created 2019/06/24 · arxiv updated 2019/06/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. While being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.

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• High-accuracy protein complex structure modeling based on sequence-derived structure complementarity
• Shedding light on the dark matter of the biomolecular structural universe: Progress in RNA 3D structure prediction
• How Pairwise Coevolutionary Models Capture the Collective Residue Variability in Proteins?
• Statistical physics of interacting proteins: Impact of dataset size and quality assessed in synthetic sequences

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