2025/12/19 by Zihao Zhu, Srijan Jhingan, Erwang Chen +1
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Genetic Mapping and Diversity in Plants and Animals #Plant Molecular Biology Research #Wheat and Barley Genetics and Pathology
paper · doi:10.1016/j.copbio.2025.103418
openalex created_date 2025/12/19 · openalex publication_date 2025/12/19 · openalex updated_date 2026/07/30
Cereal pan-genomics, powered by long-read sequencing and multi-omics integration, provides high-resolution maps of structural variants, regulatory elements, and adaptive alleles across cultivated and wild germplasm. Here, we review how these comprehensive resources uncover trait-associated variation inaccessible to single-reference approaches, enabling haplotype-informed breeding, pathway engineering, and targeted introgression of wild alleles. Integration with regulatory genomics - the study of noncoding elements controlling gene expression - and 3D genome architecture further enables precision editing of noncoding elements for phenotypic fine-tuning. Together, these advances position cereal pan-genomics as a foundational platform for predictive crop design, accelerating the development of high-yielding, climate-resilient varieties while providing actionable guidance for breeding strategies.