Evidence for a possible role of 5‐hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5‐HT re‐uptake inhibitor, reduces the capacity to perform prolonged exercise

1992/11/01 by WM Wilson, W. M. Wilson, R. J. Maughan +1
Agricultural and Biological Sciences · Medicine · #Cardiovascular and exercise physiology #Heart Rate Variability and Autonomic Control #Pharmacological Effects and Assays

paper · pdf · doi:10.1113/expphysiol.1992.sp003660

openalex publication_date 1992/11/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/29

Abstract

Seven healthy subjects exercised to exhaustion on a bicycle ergometer at a power output corresponding to 70% of maximum oxygen uptake after administration of either a placebo or 20 mg of paroxetine, a serotonin re-uptake inhibitor. Exercise time after paroxetine (median 94 min; range 84-127 min) was less (P < 0.05) than after placebo (median 116 min; range 86-133 min). The metabolic and cardiorespiratory responses to exercise were the same in both trials. This result supports the suggestion that there is a central component to fatigue which is mediated by the activity of serotoninergic neurones.

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