2026/01/01 by Samantha Henry, Geraud N Sansom, Thao Thi Phuong Tran +8 · 1 voice
Environmental Science · Medicine · #Biological Stains and Phytochemicals #Microbial Applications in Construction Materials #Photodynamic Therapy Research Studies
paper · pdf · doi:10.1039/d5md01116g
openalex publication_date 2026/01/01 · openalex created_date 2026/01/14 · openalex updated_date 2026/07/10
oxidases which are only found in prokaryotes and are therefore promising new targets, using madecassic acid and a set of synthetically modified derivatives. Our work shows that madecassic acid and its derivatives can block activity of these enzymes, while phenotypic effects in membrane and whole organism assays are more complex, consistent with modulation of multiple pathways depending upon molecular structure. This provides a new route to ursane-based antibacterial action while highlighting the importance of chemical modifications in fine-tuning biological activity of natural products.