2025/04/11 by Ella Hall-Younger, Stephen WG. Tait, Stephen W. G. Tait · 1 voice · 33 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Ferroptosis and cancer prognosis #Mitochondrial Function and Pathology
paper · doi:10.1016/j.ceb.2025.102510
openalex publication_date 2025/04/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Mitochondria are essential organelles in the life and death of a cell. During apoptosis, mitochondrial outer membrane permeabilisation (MOMP) engages caspase activation and cell death. Under nonlethal apoptotic stress, some mitochondria undergo permeabilisation, termed minority MOMP. Nonlethal apoptotic signalling impacts processes including genome stability, senescence and innate immunity. Recent studies have shown that upon MOMP, mitochondria and consequent signalling can trigger inflammation. We discuss how this occurs, and how mitochondrial inflammation might be targeted to increase tumour immunogenicity. Finally, we highlight how mitochondria contribute to other types of cell death including pyroptosis and ferroptosis. Collectively, these studies reveal critical new insights into how mitochondria regulate cell death, highlighting that mitochondrial signals engaged under nonlethal apoptotic stress have wide-ranging biological functions.