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Effects of dietary supplementation with cupreous N-carbamylglutamate (NCG) chelate and copper sulfate on growth performance, serum biochemical profile and immune response, tissue mineral levels and fecal excretion of mineral in weaning piglets

2017/07/01 by Peng Liao, Meijun Li, Yunhu Li +4
Agricultural and Biological Sciences · Pharmacology, Toxicology and Pharmaceutics · #Animal Nutrition and Physiology #Pharmacological Effects of Natural Compounds #Ruminant Nutrition and Digestive Physiology

paper · pdf · doi:10.1080/09540105.2017.1339668

openalex publication_date 2017/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

This experiment was conducted to measure the effects of dietary supplementation with copper sulfate and cupreous N-carbamylglutamate chelate (NCG-Cu) on the growth performance, serum biochemical profile and immune response, tissue mineral levels and fecal excretion of minerals of weaning piglets. Eighteen 28-d-old healthy weaning piglets (initial body weight = 6.34 ± 0.10 kg) were individually housed and randomly assigned to receive one of three diets containing no copper in either form (Control), 650 g/t copper sulfate (650 g/t Cu group) or 640 g/t NCG-Cu (640 g/t NCG-Cu group) in the final feed for 14 days. These data indicate that 640 g/t NCG-Cu was as effective as 650 g/t Cu for stimulating growth, immune response, and improving F/G in weaning piglets. Fecal Cu excretion decreased in piglets from the 640 g/t NCG-Cu group, which received 160 mg/kg Cu compared with the fecal CU excretion observed in the piglets from the 650 g/t Cu group, which also received 160 mg/kg Cu. Therefore, 640 g/t NCG-Cu of dietary Cu, may provide an effective environmental alternative to 650 g/t Cu in weaning piglets.Abbreviations: ADFI: average daily feed intake; ADG: average daily gain; ALB: albumin; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate amino transferase; CK: creatine kinase; CREA: creatinine; D-BIL: direct-acting-bilirubin; F/G: feed/gain ratio; GLB: globulin; GLU: blood glucose; IgA: immunoglobulin A; IgG: immunoglobulin G; LDH: lactate dehydrogenase; NCG: N-carbamylglutamate; T-BIL: total bilirubin; TC: total cholesterol; TP: total protein; urea: Urea; UA: urate

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