2017/12/18 by Yuan Shao, Weiwei Heng, Shanshan Li +2
Health Professions · Medicine · Nursing · #Clinical Nutrition and Gastroenterology #Dysphagia Assessment and Management #Hyperglycemia and glycemic control in critically ill and hospitalized patients
paper · pdf · doi:10.1002/jpen.1035
openalex publication_date 2017/12/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27
Abstract Background Glycemic control is essential for managing acute stroke. This study evaluated the impact of a diabetes‐specific formula (DSF) on glycemic control in severe acute ischemic stroke patients. Methods A randomized, prospective controlled trial was conducted in Nanjing Drum Tower Hospital. Acute ischemic stroke patients who scored > 10 on the National Institutes of Health Stroke Scale as well as had swallowing problems were randomized to group A, which received a diabetes‐specific enteral formula, and group B, which received a standard formula. Glycemic parameters were assessed at baseline and 7 days after admission. Results One hundred four patients were enrolled in the study (group A, 53; group B, 51). Postprandial glucose parameters, including capillary glucose concentration from 8 hours to 16 hours after enteral nutrition (EN) consumption, incremental areas under the curve (iAUC 0‐16 h ), peak value, and mean glucose concentration, were significantly lower in group A than in group B following a 7‐day intervention period. Moreover, changes in HOMA IR after the 7‐day treatment were significantly higher in group A than in group B. No significant difference in the incidence of hypoglycemia, glycemic variability parameters, or nutrition parameters was found between the 2 groups, either at baseline or after treatment. There were no serious adverse events observed during the study. Conclusion A diabetes‐specific formula may improve acute‐term glycemic control in severe acute ischemic stroke patients.