Advances towards potential cancer therapeutics targeting Hippo signaling

2024/12/06 by Rui Zhu, Zhihan Jiao, Fa‐Xing Yu · 1 voice
Biochemistry, Genetics and Molecular Biology · #Hippo pathway signaling and YAP/TAZ

paper · doi:10.1042/bst20240244

Abstract

Decades of research into the Hippo signaling pathway have greatly advanced our understanding of its roles in organ growth, tissue regeneration, and tumorigenesis. The Hippo pathway is frequently dysregulated in human cancers and is recognized as a prominent cancer signaling pathway. Hence, the Hippo pathway represents an ideal molecular target for cancer therapies. This review will highlight recent advancements in targeting the Hippo pathway for cancer treatment and discuss the potential opportunities for developing new therapeutic modalities.

Citations

• The Hippo Signaling Network and Its Biological Functions
• The Hippo Pathway: Biology and Pathophysiology

Discussions

• The Hippo pathway is frequently dysregulated in human cancers and represents an ideal therapeutic target. Find out about the advances in targeting the Hippo pathway for cancer treatment this #BiochemS [bsky, 8 points, 0 comments]

Related

• The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
• The Hippo Signaling Network and Its Biological Functions
• The Hippo Pathway: Biology and Pathophysiology
• PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
• RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS