Ticket to ride: export of proteins to the Plasmodium falciparum‐infected erythrocyte

2016/03/21 by Jude M. Przyborski, Britta Nyboer, Michael Lanzer · 1 citation
Medicine · #Drug Transport and Resistance Mechanisms #Malaria Research and Control #Mosquito-borne diseases and control

paper · pdf · doi:10.1111/mmi.13380

openalex publication_date 2016/03/21 · openalex created_date 2016/08/23 · openalex updated_date 2026/07/30

Abstract

The malaria parasite Plasmodium falciparum exports numerous proteins to its chosen host cell, the mature human erythrocyte. Many of these proteins are important for parasite survival. To reach the host cell, parasites must cross multiple membrane barriers and then furthermore be targeted to their correct sub-cellular localisation. This novel transport pathway has received much research attention in the past decades, especially as many of the mechanisms are expected to be parasite-specific and thus potential targets for drug development. In this article we summarize some of the most recent advances in this field, and highlight areas in which further research is needed.

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