JAK/STAT signaling in stem cells and regeneration: fromDrosophilato vertebrates

2019/01/15 by Salvador C. Herrera, Erika A. Bach, Erika A Bach
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Neuroscience · #Developmental Biology and Gene Regulation #Invertebrate Immune Response Mechanisms #Neurobiology and Insect Physiology Research

paper · doi:10.1242/dev.167643

openalex publication_date 2019/01/15 · openalex created_date 2019/02/21 · openalex updated_date 2026/07/30

Abstract

ABSTRACT The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling is best known for its roles in immunity. However, recent work has demonstrated that it also regulates critical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in several tissues, including the gonad, intestine and appendages. Here, we provide an overview of JAK/STAT signaling in stem cells and regeneration, focusing on Drosophila and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates.

Citations

• The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration
• The Digestive Tract of Drosophila melanogaster

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