2014/07/17 by Claudio Dalvit, Christian Invernizzi, Anna Vulpetti · 1 citation
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Fluorine in Organic Chemistry #Inorganic Fluorides and Related Compounds #Molecular Spectroscopy and Structure
paper · doi:10.1002/chem.201402858
openalex publication_date 2014/07/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Hydrogen-bonding interactions play an important role in many chemical and biological systems. Fluorine acting as a hydrogen-bond acceptor in intermolecular and intramolecular interactions has been the subject of many controversial discussions and there are different opinions about it. Recently, we have proposed a correlation between the propensity of fluorine to be involved in hydrogen bonds and its (19)F NMR chemical shift. We now provide additional experimental and computational evidence for this correlation. The strength of hydrogen-bond complexes involving the fluorine moieties CH2F, CHF2, and CF3 was measured and characterized in simple systems by using established and novel NMR methods and compared to the known hydrogen-bond complex formed between acetophenone and p-fluorophenol. Implications of these results for (19)F NMR screening are analyzed in detail. Computed values of the molecular electrostatic potential at the different fluorine atoms and the analysis of the electron density topology at bond critical points correlate well with the NMR results.