2016/07/06 by Johanna Novacek, Lukas Roiser, Katharina Zielke +2
Chemistry · #Organic Chemistry Cycloaddition Reactions #Synthesis and Catalytic Reactions #Asymmetric Synthesis and Catalysis
paper · doi:10.1002/chem.201602052
The key factors for carbonyl-stabilised ammonium ylide-mediated epoxidation reactions were systematically investigated by experimental and computational means and the hereby obtained energy profiles provide explanations for the observed experimental results. In addition, we were able to identify the first tertiary amine-based chiral auxiliary that allows for high enantioselectivities and high yields for such epoxidation reactions.