The concept of allostasis in biology and biomedicine

2003/01/01 by Bruce S. McEwen, Bruce S McEwen, John C Wingfield +1 · 3,269 citations
Medicine · Neuroscience · Psychology · #Adipose Tissue and Metabolism #Allostasis #Allostatic load #Birth, Development, and Health #Neuroscience #Psychology #Stress Responses and Cortisol

paper · open access · doi:10.1016/s0018-506x(02)00024-7

published in Hormones and Behavior 43(1), 2-15 (Elsevier BV)

openalex publication_date 2003/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Citations

• Stress and the Individual

Cited by

• House sparrows (Passer domesticus) adjust their social status position to their physiological costs
• A role for corticosterone and food restriction in the fledging of nestling White storks
• Quantifying resilience of humans and other animals
• What is Balance? A Vital Mechano-Regulation Paradigm
• Brain on stress: How the social environment gets under the skin
• Expression of glucocorticoid receptor in the intestine of a euryhaline teleost, the Mozambique tilapia (Oreochromis mossambicus): Effect of seawater exposure and cortisol treatment
• Stochastic model for analysis of longitudinal data on aging and mortality
• Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
• From eggs to adulthood: sustained effects of early developmental temperature and corticosterone exposure on physiology and body size in an Australian lizard
• Adverse childhood experiences, allostasis, allostatic load, and age-related disease
• A users guide to HPA axis research
• Getting slimmer without dieting or exercising: zebra finches can rapidly lose mass while maintaining food intake and decreasing activity
• Cardiac autonomic balance versus cardiac regulatory capacity
• Psychological Resilience: An Affect-Regulation Framework
• The neuroendocrinology of stress: the stress-related continuum of chronic disease development
• The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity
• Evolutionary ecophysiology in extreme environments under a global change scenario
• The Dual-Loop Model of Psychophysiological Regulation: A Framework for Psychological Breakthrough and State Transition
• WITHDRAWN
• Activation of the sympathetic-adrenal-medullary system increases DNA damage during the transition to captivity
• Psychosocial and neurobiological aspects of the worldwide refugee crisis: From vulnerability to resilience
• Passerine stopover physiology: weather variability does not alter corticosterone dynamics after sea crossing
• Dual‐axis hormonal covariation in adolescence and the moderating influence of prior trauma and aversive maternal parenting
• Unpredictability and adaptive responses to dietary variability in Japanese quail
• A Systems Approach to Homeostasis: What Euryhaline Fish Teach Us About Organismal Stress Responses
• Dermal glucocorticoids are uncoupled from stress physiology and infection
• Non‐lethal effects of climate change and infectious disease: An energetics approach to understanding population impacts
• Unveiling stress markers: A systematic review investigating psychological stress biomarkers
• Surfing uncertainty with screams: predictive processing, error dynamics and horror films
• Abnormal thyroid function is common in takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study
• Seasonal variation in hormonal responses of timber rattlesnakes (Crotalus horridus) to reproductive and environmental stressors
• Molecular, behavioral, and performance responses of juvenile largemouth bass acclimated to an elevated carbon dioxide environment
• Glucocorticoid responses of wildlife to anthropogenic stressors are influenced by disturbance type and species traits
• Investigating Metrics of Discrete-Individual Repeatability of the Stress Response
• Stress revisited: A critical evaluation of the stress concept
• Mental fatigue: Costs and benefits
• A conceptual framework for the neurobiological study of resilience
• Life-history strategy mediates the effects of multiple developmental stressors on Australian lizards
• On Using Large Language Models to Enhance Clinically-Driven Missing Data Recovery Algorithms in Electronic Health Records
• Personality trait structures across three species of Macaca, using survey ratings of responses to conspecifics and humans
• Standard methods for marking caudate amphibians do not impair animal welfare over the short term: An experimental approach
• A dynamic concept of animal welfare: The role of appetitive and adverse internal and external factors and the animal’s ability to adapt to them
• Influence of sea ice concentration, sex and chick age on foraging flexibility and success in an Arctic seabird
• From trauma to resilience: psychological and epigenetic adaptations in the third generation of holocaust survivors
• The Human Affectome
• Social support and perceived partner responsiveness have complex associations with salivary cortisol in married couples
• Biological validation of faecal corticosterone metabolites as a non-invasive stress assessment in translocated California valley quail (Callipepla californica)
• The gut microbiota–brain axis in behaviour and brain disorders
• The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited
• Tracking biocultural pathways in population health: The value of biomarkers
• Adrenocortical and autonomic cross-system regulation in youth: A meta-analysis
• Allostatic Load and Its Impact on Health: A Systematic Review
• Fecal glucocorticoid metabolites stabilize following the transition of free-ranging orphaned wild polar bear cubs into human care
• Similarities and differences in carotid artery, hemodynamic, and autonomic reactivity induced by mental stress or cold in adults: A randomized crossover study
• Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health
• Integration of lung function in allostatic load scoring and its impact on mortality prediction
• Methods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study
• Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
• An integrative appraisal of the hormonal and metabolic changes induced by acute stress using king penguins as a model
• Potential for population-level disturbance by active sonar in herring
• Assessing Stress in Zoo-Housed Western Lowland Gorillas (Gorilla gorilla gorilla) Using Allostatic Load
• Drop dead! Female mate avoidance in an explosively breeding frog
• Interdependence of the properties and structure of high-T/sub c/ Nb--Ge films
• Do glucocorticoids indicate stress? Meta-analysis reveals a tight association between glucocorticoids and metabolic rate
• Behavioural changes in African elephants in response to wildlife tourism
• Clinical staging and serum cytokines in bipolar patients during euthymia
• Treatment-related reductions in PTSD and changes in physical health symptoms in women
• Are glucocorticoids good indicators of disturbance across populations that exhibit cryptic variation in contaminant tolerance?
• Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
• 云南马厂箐岩体(似)斑状花岗岩锆石LA-ICP-MS U-Pb年龄及地质意义
• Protective and damaging effects of stress mediators: central role of the brain
• Behavioral and physiological female responses to male sex ratio bias in a pond-breeding amphibian
• Type 2 diabetes mellitus and psychological stress — a modifiable risk factor
• Parental care, loss of paternity and circulating levels of testosterone and corticosterone in a socially monogamous song bird
• Dynamical System Modeling of Self-Regulated Systems Undergoing Multiple Excitations: First Order Differential Equation Approach
• Stress, depression, and anhedonia: Caveats concerning animal models
• Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs. [europepmc]
• Hormone-mediated maternal effects in birds: mechanisms matter but what do we know of them? [europepmc]
• Cardiac autonomic balance versus cardiac regulatory capacity. [europepmc]
• Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. [europepmc]
• Is segregation bad for your health? [europepmc]
• What is in a name? Integrating homeostasis, allostasis and stress. [europepmc]
• Attenuation of cortisol across development for victims of sexual abuse. [europepmc]
• Upward spirals of positive emotions counter downward spirals of negativity: insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology. [europepmc]
• Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. [europepmc]
• The Adaptive Calibration Model of stress responsivity. [europepmc]
• Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor. [europepmc]
• Migraine: multiple processes, complex pathophysiology. [europepmc]
• Sleep Deprivation and Circadian Disruption: Stress, Allostasis, and Allostatic Load. [europepmc]
• Mechanisms of stress in the brain. [europepmc]
• Measures of physiological stress: a transparent or opaque window into the status, management and conservation of species? [europepmc]
• Can Interoception Improve the Pragmatic Search for Biomarkers in Psychiatry? [europepmc]
• Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. [europepmc]
• A users guide to HPA axis research. [europepmc]
• Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review. [europepmc]
• An energetic view of stress: Focus on mitochondria. [europepmc]
• Quantifying resilience of humans and other animals. [europepmc]
• An Active Inference Approach to Interoceptive Psychopathology. [europepmc]
• Psychological interventions to foster resilience in healthcare professionals. [europepmc]
• Mental health and clinical psychological science in the time of COVID-19: Challenges, opportunities, and a call to action. [europepmc]
• Psychological Resilience: An Affect-Regulation Framework. [europepmc]