One-Pot Synthesis of [1,2,3]Triazolo[1,5-a]quinoxalin-4(5H)-ones by a Metal-Free Sequential Ugi-4CR/Alkyne–Azide Cycloaddition Reaction

2019/11/25 by Yan-Mei Yan, Yan‐Mei Yan, Haoyang Li +9
Chemistry · #Click Chemistry and Applications #Multicomponent Synthesis of Heterocycles #Synthesis and Biological Evaluation

paper · doi:10.1055/s-0037-1610737

openalex publication_date 2019/11/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

A convenient and one-pot approach to prepare [1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-ones by a metal-free sequential Ugi-4CR/alkyne–azide cycloaddition reaction has been developed. The reaction of 2-azidobenzenamines, aldehydes, propiolic acids, and isocyanides produced the Ugi adducts, which were transformed to the [1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-ones in moderate to good yields via alkyne–azide cycloaddition reaction.

Citations

• A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions

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